Projects

Pro-Limb

Healthcare software development, healthcare AI, Big Data

  • Dr. Péter Maróti
  • Dhakshinamurthy Devaraj
  • Dr. Ádám Schiffer

Upper extremity prostheses development in the PTE 3D Centre (PTE MIK, PTE 3D Centre)

Tamás Storcz (PTE MIK) – interior localization

InnoTeq Kft. – Péter Rendes, Immersive experiences on both sides of space

László Gelányi – Phoenix Orthosis

Optin Kft. – Dr. Zoltán Kovács, Medical IT software development with Optin Kft.

Ember Arm – the freedom of movement without compromises!

The newly developed upper extremity prosthesis of Pro-Limb could mean the reclamation of full life and productivity for millions worldwide.

Our product is myoelectonrically controlled upper extremity prosthesis created by an experienced group of medical, rehabilitation and engineering experts that is cost-effective, innovative and manufactured mostly by 3D printing technologies.

Partial or full upper extremity amputations affect nearly 3.6-5.0 people worldwide; it is hard to give an accurate estimate, since most of these people live in developing countries. The number of upper extremity amputations in Hungary is about 200-250 yearly, most of them with a trauma (accident) background. The bone structure of the majority of patients would allow them the use of highly functional upper extremity prostheses, but the price of these devices is extremely high – starting from around 6 million HUF – and it is only partly or not at all covered by state insurance. The goal of our development is to provide an affordable, but functionally compromise-free solution for these patients both in Hungary and internationally to promote the reintegration into active society, and the workforce.

Cutting-edge technology in service of everyday life

The advanced functions of Ember Arm make handling everyday routine possible for patients with genetic and acquired limb loss. The base structure and the outer covering are 3D printed fully tailored to the needs of the patient. It provides uniqueness to the patient in material, colour, size or anthropomorphic appearance.

The other giant benefit is that the patient does not have to learn the permanent muscle functions of the arm; the gestures of the prosthesis can be taught with the use of an artificial intelligence software. With the help of the prescribed movements, the classification parameters are easy to recalibrate and download to a microcontroller in the arm. The arm will then execute the decision-making based on the new parameters about specific gestures. The prosthesis knows many functions needed in everyday life (e.g. carrying, holding, adaptive adjustment of gripping force in various environments etc.), the settings for these are simple, available in a mobile app. Among the innovative solutions are the vibration responses when touching objects, the save grip on amorphous objects, and the easy reparability.

Cost-value ratio – unique product category

We have considerable benefits over our competitors. One of the most important is the outstanding cost-value ratio: devices with similar functionality can cost ten millions of forints, and prostheses at similar price points cannot be fully customized. Ember Arms is a completely new product category, since it is optimized for everyday activities (AoDL – activities of daily living), the quantity of available settings of freedom allow for precise movements; however, the final cost is only a fraction of the products manufactured by large industrial companies.

Learning module – adherence, reliability

Our unique and niche solution is “Training-Prosthesis”. It aims to allow for post-amputation rehabilitation to start early, in the first week weeks after operation. It allows the preparation of the client for the usage of the final customised device. The “Training-Prosthesis” differs from the final version in the number of motors and adjustable movement patterns (since having unlimited movement patterns is not relevant yet). The learning module is supported by a gamified VR application, that not only increased adherence, it provides an opportunity for objective feedback for the physiotherapist or rehabilitation expert. The development is based on the internationally acclaimed SHAP test. We aim to not only decrease the number of prosthesis loss, but to provide exact feedback to the physiotherapist/technician/provider with the status of the device. This data will be important both for the provider and the financer (Eg. NEAK, insurance companies).

Inbuilt Artificial Intelligence – limitless in movement

The AI controlling the arm allows it to learn unique movement and gripping patterns. While other products have a limited number of movements, the result of our development is a device capable of an arbitrary number of movements, providing clients with optimal functions. The vibro-tactile feedback further aids the user. This function only provides information about the battery status of the device in our competitor’s products; the vibro-tactile feedback of the Ember Arm increases adherence in the user by creating the sensation of touch.

Gripping amorphous objects – increasing functionality

The individual movement of all five fingers in an important feature, because it allows the gripping of amorphous objects. All fingers have individual motors and the shape of joints allow the hand to mould to the surface – this way, the hand can grip difficult shapes and non-solid objects as well.

Unique design – a break from tradition

Our competitors follow two main approaches in design and outer appearance. One option is creating an appearance very close to real hands and arms, and other is the futuristic, “robotic” appearance. We believe that our clients should not have to compromise in creating their new body image. There will be an option to keep the “robotic” design, but the clients will be able to choose an anthropomorphic appearance as well with an aesthetic covering. The development background of the University of Pécs orthopaedic-engineering course supports the local implementation of the technology.

Members of our development group

  1. Devaraj Dhakshinamurthy, development leader: “Engineering is about creating practical solutions to the problems society faces. I aim to use my expertise in robotics to help provide affordable devices to the people who need them.”
  2. Csaba Csóka, the manager of Pro-Limb, the company developing and manufacturing Ember Arm, has a 30-year expertise in the field. He is the founder of Corvus Med, the company dealing with manufacture and sales of healthcare equipment and operating specialised clinics for the rehabilitation of disabled patients. He is one of the oldest representatives of Ottobock in Hungary.
  3. Dr. Luca Tóth is a medical expert, the contact of clinical studies, the leader of the PTE Neurorehabilitation workgroup, researcher. She has been working with exoskeletons and connected human studies in practice for years.
  4. Dr. Péter Maróti is the project leader, product developer medical researcher and the development leader at the University of Pécs 3D Printing and Visualization Centre. He has multiple years of experience in the implementation the medical uses of 3D printing technologies and visualization (VR) techniques.
  5. János Mendler is a leader of the CAD design group, a senior mechanical engineer. He is a 3D designer, the expert in advanced machine industry design applications. His main field of expertise is 3D computer based (3D CAD) design, model making, form design and product development; creation, reworking and digitizing machine designs; designing educational materials, identifying geometric and physical characteristics.
  6. Dr. Ádám Schiffer, senior firmware developer engineer – university associate professor. His main fields are measurement theory, signal processing, image processing, analysis of nonlinear systems, hysteresis characteristics of magnetic materials, autonomous robots.

A summary of the benefits of our product

  • cost-value ratio – high functionality at an affordable price
  • Learning unique movement patterns – AI control
  • Learning version and professional version
  • Vibro-tactile feedback
  • Training: gamified mobile app
  • Modular: can be attached regardless of place of amputation
  • Independent movement of all 5 fingers – gripping amorphous objects
  • Learning module – rehabilitation, tracking

The Ember Arm provides outstanding functionality for people with upper extremity loss. The development has many innovative, supportive, stimulating solutions that help use. It’s cost-value ratio elevates it from the competition. An important development is the existence of a device learning module with the matching prosthesis that allows for the early start of rehabilitation. It also help to identify the direction of development, an important factor for the health insurance system as well.

M3D-Vision

Healthcare software development, healthcare AI, Big Data

  • Dr. Péter Maróti

Live broadcast and recording of medical content with 3D technology, with an educational material editor medule

Participants

Dr Péter Maróti – medical professional expert, project leader, inventor

Mátyás Bene – IT engineer, embedded systems expert, inventor

Attila Péntek – IT engineer, hardware developer, inventor

Emese Molnár – Head of development

Árpád Sipőcz – VR expert, Unity developer

Development partner: CA Engineering Kft.

Description

„M3D-Vision” is an interactive healthcare 3D content recorder and player frame system that aims to relieve and redesign healthcare education. Using live, edited, real 3D content and virtual reality (VR) elements, it aims to create and revolutionize digital healthcare content creation and quality assurance. Its main uses could be recording and displaying 3D digital content, providing relief to clinical staff, improving the general quality of education and providing quality assurance for surgeries.

The development is in its advanced stages: the hardware and software for a functional prototype are already available. There are successful tests running at the PTE Medical School Simulation Education Center. For the further development and market launch of the development we would need tender sources, venture-capitalists or targeted financial support, for which we are actively looking for.

The M3D-Vision system is a complete hardware and software pack that allows 2D or 3D technology recording of voice or video materials in clinical environments. It also contains a user-friendly option for editing the recordings and the uploading and sharing of interactive content. The 3D interactive healthcare content recorder and player pack serves to renew and give relief to healthcare education and service. Universities, medical students, clinics, public schools should all be able to benefit from the equipment, helping education, research or even medical work. The model is currently unique in its flexibility and feasibility. The development focuses on both hardware and software development, and the integration of use cases (e.g. surgery streaming for education, documentation or consultation). Our product reached its current, advanced even in international circles of similar ideas, status due to intensive development and real-life practical review. The current level of development can already be used for research, demonstration and education.

Key elements

3D recording mode

The system can record 2D or 3D content that can be annotated and extended with interactive content live or post-recording in a user-friendly way.

Editable, recordable visualization processes

Recorded videos are easy to edit, the most important content can be emphasized using various visualization processes. Videos can be organised in searchable and shareable libraries.

Real-time data forwarding

The system allows the streaming of surgery or classroom recording to an arbitrary number of users. The image content can be supplemented with VR content with the use of a 3D pointer in the surgery setting. The software is a multiplatform development, therefore it is easy to integrate and use in a variety of imaging devices.

Modular system

Institution or personal user licences, personalised solutions. The system can be integrated into existing LMS (Learning Content Management) or LCMS (Learning and Content Management Systems) systems, but it also functions as a stand-alone frame system. Users can access the system both individually and on the institutional level; licence management was designed accordingly.

We are cooperating with CAE Engineering Kft., they are the Hungarian subsidiary of a multinational (Canada-based) company providing military, airplane and healthcare simulation solutions. Therefore, the system will be available in these fields as well for education and quality assurance.

Other than 3D visual data, depth data can also be extracted from the system, allowing for the forwarding, storage and analysis of real parametric spatial information as well.

During the hardware development on the input side we have successfully created the prototype of a 3D pointer that can be sterilized and used in clinical environments, as well as a universal stand that can be used in both surgery and classroom environment – it can even be placed in a surgery lamp. The camera can be placed on the surgeon’s head with a special band, providing the surgeon’s POV. A small external computer attached to a belt, allowing for comfortable and hassle-free use, handles the streaming of digital content and data processing. Moreover, the device is plug-and-play to ensure the easiest possible operation for users.

Our current partners are from the healthcare industry, but we firmly believe that our development could provide valuable services for the industry, security techniques or even representatives of the defensive areas.

References, awards, press/media appearances

  • PTE Innovation Award, 2017
  • InnoPécs 2019 presentation, 24 April 2019, PTE MIK (Mátyás Bene)
  • EIT Health “HUB Collaborations” Innovation Days in Pécs presentation: 19-20 November, 2019 (Dr. Péter Maróti)
  • PTE MIK Partner’s Day presentation, 17-18 October, 2019: (Mátyás Bene, Emese Molnár)
  • Awards for the most innovative university students in Pécs (Pécsi Újság)
  • 3D successes on the PTE Innovation Day (PTE ÁOK News)

Website

medvision.hu

Lower and upper extremity movement analysis

Healthcare software development, healthcare AI, Big Data

  • Dr. Ádám Schiffer
  • Dr. Miklós Gerzson
  • Péter Müller
  • Anett Nagyváradi
  • Dr. Levente Szabó
  • Tamás Storcz
  • Zsolt Kisander
  • Dr. Márk Virág
  • Lower and upper extremity movement analysis data gathering from healthy and disabled patients
  • Filtering movement data
  • Identification of movement phases, design of models needed for the process
  • Similarity measurement: identification of a system for measuring similarities in ideal and measured movement patterns, factor analysis (ICA, PCA) with AI assistance
  • Recording sport movement patterns (e.g. throwing), comparison of measured patterns with ideal patterns
  • creation of a 3D skeleton model

Contact: PTE Department of Neurosurgery, Dr. Luca Tóth

AR-VR software development (for prosthetics and the M3D Vision project)

Healthcare software development, healthcare AI, Big Data

  • Zoltán Vass

Contact: Emese Molnár, PTE 3D Centre

Connected research group: Medical Material Technology

Studies about eyesight

Healthcare software development, healthcare AI, Big Data

  • Dr. Géza Váradi

Contact: Dr. Péter Buzás (PTE ÁOK), János Radó (PTE ÁOK)

IT developments

Healthcare software development, healthcare AI, Big Data

  • Zsolt Schaffer
  • István Balogh

    Project management of TEP research groups, shared messaging, shared storage space

    Contact: Dr. József Ulbert, Faculty of Natural Sciences Head of Department

Surgery planning 1 – Orthopaedics

Simulation education, surgery planning and Operational Medicine

  • Dr. Péter Than
  • Dr. Csaba Vermes
  • Dr. Ádám Schlégl
  • Dr. Kristóf József

The key to scoliosis correction surgery is the bend of retainer rod. In the course of our research cooperation with EOS Imaging Ltd. SpineEOS, we would study the accuracy of their retainer rod designer software, providing development ideas for the company.

In the new process, we would use the software for 3D printed rod templates for the further refinement of the rod’s shape after preoperative EOS imaging and 3D reconstruction.

After the surgery, we would use EOS imaging to find the differences between the two design methods, and the accuracy of the design.

Possible achievements, goals, commitments

We can definitely commit to an external partnership cooperation with EOS Imaging Ltd, Paris. We cannot promise Q2 level articles, but in optimal circumstances, the contents should be ready by March.

Surgery planning 2 – Dentistry, dental surgery

Simulation education, surgery planning and Operational Medicine

  • Dr. Gyula Marada
  • Dr. Zsanett Kövér

With the opening of the 3D centre the opportunity for establishing digital dentistry at the clinic also opened to us. The primary studies were started by two workgroups. The main field of the first group was the study of accuracy in surgeries with 3D printed templates.

The second workgroup focused on the possible connections of digital techniques and virtual design in dental surgeries. Such surgeries could be disgnath and bone replacement surgeries and dental implantation rehabilitation.

Possible achievements, goals, commitments

We are committed to building connections with leading members of the local innovative market who take part in the implementation of virtual designs in real life. A potential partner could be Dent Art Kft, under the leadership of János Kónya. He has even implemented a product award patent in the past.

We are also committed to the publication of our findings in international scientific journals.

Simulation education

Simulation education, surgery planning and Operational Medicine

  • Dr. Szilárd Rendeki
  • Dr. Bálint Nagy
  • Péter Szűcs
  • Mátyás Rendeki

The PTE ÁOK Simulation Education Centre develops manual skill education tools and education method possibilities for medical school gradual and post-gradual course goals at 21st century standards. We are working on the expected education system of practical elements with the available equipment, aiming to satisfy the needs of individual clinical professions. This will contain the achieved and still to be gained and improved skills in an easy to measure, objective and recorded format for our students and graduated doctor colleagues.

Possible achievements, goals, commitments

A system documenting professional development could help registered colleagues in acquiring the technical elements of their field of choosing. In order to identify the objective measurement parameters, we will create a simulator qualification system, which will be able to prove the real educational use and success of our simulator system emulating real life practical skills, taking into account the views of users, students and administrators. Gathering this data will help us in getting to know the future direction of simulation education, its failings; development and maintenance will be easier to plan after data analysis as well. We are identifying a unified, national professional education concept with the foundation and active work of the Hungarian Healthcare Simulation Association.

We are committed to publishing our achievement in international academic journals.

Operational Medicine

Simulation education, surgery planning and Operational Medicine

  • Dr. Szilárd Rendeki
  • Dr. Bálint Nagy
  • Dr. Ildikó Bock-Marquette
  • Dr. Zsófia Nagy
  • Dr. Klaudia Maár
  • Péter Szűcs
  • Mátyás Rendeki

We teach, research and develop injury treatment methods in law enforcement, military and special environment. We analyse the topic of pre-hospital life-saving while taking the local situation into account – therefore we change international experience and knowledge accordingly. The complex, modular general education concept of Operational Medicine encompasses the creation of rural life-saving programmes, medical professional training and professional upskilling. Our Operational Medicine programme deals with early diagnostic recognition of special injury types, the study of the effects of extreme physical and mental stress on performance and opportunities to preparation in cooperation with the Central European Police Academy. The group actively participates in the work of the NATO human exoskeleton research group.

We are committed to publish our achievements in international scientific journals.

Comparative clinical trial to develop a new type of diagnostic method for non-alcoholic fatty liver disease (clinical outpatient material)

Biocybernetics and Medical Robotics Research Group

The aim of the research

Development of a new type of bedside, non-invasive, low-cost device and procedure that would detect significantly less fat (less than 25%) at a lower cost than current diagnostic methods.

The research process

Study of the bioimpedance spectrum of morbidly obese patients (patient material of the Department of Surgery, Prof. Dr. András Vereczkei); bioimpedance study of patients with other endocrine diseases who are morbidly obese (patient material of the 1st Department of Internal Medicine, Prof. Dr. László Bajnok); bioimpedance study of patients with carcinoma of the liver (patient material of the Department of Surgery, Dr. Károly Kalmár Nagy); bioimpedance study of patients with liber fibrosis (patient material of the 1st Department of Internal Medicine, Dr. habil Gabriella Pár).

Development of a bioimpedance-based, non-destructive virus infection detection method

Biocybernetics and Medical Robotics Research Group

The aim of the research: rapid detection of pathogens; early confirmation of the presence of the infection is one of the most important tasks in stopping and preventing the spread of the disease. Our successful developments would make it possible to routinely and quickly detect viruses that cause infections.

The bioimpedance-based measurement method we developed is suitable, with virus-dependent dynamics (Zika virus in the present experiment), to detect the early phase of the infection, days before the detection possibilities of today’s methods. In the next stage of our research, the early detection of particularly dangerous, BSL-4-level, viral infections could provide an opportunity for rapid intervention in the case of epidemics.

3D Bioprinting with special regard to lung diseases and modeling of their vascular network

Bioprinting

  • Prof. Dr. Judit Pongrácz
  • Dr. Veronika Csöngei
  • Dr. Luca Járomi
  • Dr. Aldelwahab Mohamed Elhusseiny

Leading the bioprinting working group, with special regard to lung and vascular diseases and applications, preparation of clinical use through OGYÉI negotiations (Prof. Dr. Judit Pongrácz)

Creation of a 3D blood-brain barrier model, especially with the aim of studying the penetration of lung tumors (Dr. Veronika Csöngei)

3D aggregation of aggregation-resistant lung tissues through the application of magnetic methods (Dr. Luca Járomi)

Modeling of LAM (lymphangioleiomyomatosis), a rare human lung disease of genetic origin with human cell lines and primary cultures (Dr. Aldelwahab Mohamed Elhusseiny)

Traditional and alternative areas of application of the 3D bioreactor

Bioprinting

  • Dr. Krisztián Kvell
  • Krisztina Bánfai
  • Judit Bóvári-Biri
  • Levente Ornódi

Leading the bioreactor working group in both traditional (culture) and alternative (toxicology, stem cell differentiation) areas of application (Dr. Krisztián Kvell)

Development of toxicological homunculus (human organ systems) in a 3D bioreactor, validation with known active substances and preparation for testing new active ingredients (Krisztina Bánfai)

Study of the tissue differentiation of stem cells (primary or induced) in a 3D bioreactor concerning bone and cartilage tissue (Judit Bóvári-Biri)

Preparation of the 3D bioreactor for regular and temporary, cellular and other activities (Levente Ornódi)

Further scientific activities

Bioprinting

  • Dr. Szilárd Pál
  • Dr. Alexander Széchenyi
  • Dr. György Miskei

Artificial neural network data evaluation (Dr. Szilárd Pál)

Nanotechnological materials science innovations (Dr. Alexander Széchenyi)

Professional English language activity in the development of publications and teaching materials (Dr. György Miskei)

ITSH Comfort in workspaces

Parameterized comfort in physical spaces

We have expanded the faculty's existing cooperation with IT-Services Hungary. The aim of the project is to study the relationship between work comfort and work efficiency at the Budapest and Debrecen sites.

The aim of the research is to increase the comfort of the employees and reduce health risks by studying and evaluating the physical properties of the existing office building that is the subject of the research. In order to enhance individual comfort, the main task of the research group is to develop a complex design method that helps to create and use a built environment, especially interiors, which uses solutions that reduce health risks and can be operated in a sustainable way.

Our research group works in the frame of a cooperation with ITSH Ltd. During the study, the data collection was aimed at mapping the subjective comfort on the one hand, and the instrumental measurement of the effects that could potentially determine the comfort of the employees on the other - carbon dioxide concentration, noise level, light conditions, temperature, and humidity.

Measuring instruments

  • TESTO 480 - air conditioning and ventilation measuring instrument
  • TESTO 315-3 - environmental CO / CO2 meter
  • KIMO LX 200 LUXMETER
  • NTI Audio & Acoustic XL2
  • TROTEC BZ25 CO2 air quality monitor

Sustainability of residential buildings, comfort

Parameterized comfort in physical spaces

Sustainability is a key consideration in the development of contemporary residential building concepts. The sustainability of a building can be characterized by its durability, i.e. the lifespan of the building, the determining element of which is the relationship of the building’s structural and functional properties. The aim of the research is to study the structural and functional lifespan of residential buildings, to map the possibilities of striking a balance between them based on the revealed data and connections. The condition for this is adaptability, which can be ensured by the selection of structural systems and materials optimised for this purpose. Based on the above, our goal is to develop a structural system with the help of which a designed residential building can ensure the desired transformability, considering the static and acoustic needs, while at the same time it can provide a high level of comfort for the residents as well.